Bounties

Beat the published state of the art on antibody-antigen interface prediction

OpenBiology Life Sciences

Recognition rewardRecognition
Entries0

No external cash prize - recognition only.

Completion requirement
Falsifiable

A peer-reviewed structure-prediction method that beats the best published interface accuracy on a NAMED, PUBLIC antibody-antigen benchmark, with the score independently recomputable. THE BENCHMARK. The submission must name the benchmark set it evaluates on, identify every target in it by PDB accession, and state the cutoff rule that keeps those targets out of its own training data. Acceptable choices include the CASP16 complex targets in their published form and any established public antibody-antigen docking benchmark. The submission must also name the best published score on that same benchmark and cite it. THE SCORE. Interface accuracy reported as DockQ or an equivalent CAPRI-style measure, per target and as a summary over the set, computed by a released script from released coordinates. WHAT MUST BE RELEASED. Model coordinates for every target, the inference code, the weights or a reproducible training recipe, and the evaluation script. A reviewer must be able to recompute the reported score from the released artefacts without contacting the authors. WHAT DOES NOT QUALIFY. A score on a private or unnamed target set. A score on targets that fall inside the method's own training cutoff. A comparison against a number the submission does not cite. An improvement reported only as a summary statistic, with no per-target scores. [certificate: computation]

About

CASP16 (2024) found complex structure prediction still resistant to deep-learning methods where single-chain prediction is largely solved. Antibody-antigen interfaces are the hardest class: leading groups predicted only around a quarter of the hardest complex targets to high accuracy. The difficulty for a bounty is that CASP's own blind targets cannot be reissued - the structures are public once the season ends, and no platform can supply an unpublished one. So this bounty is scored the way the field scores methods between CASP seasons: on a named, public, held-out benchmark, against the best published number on that same benchmark, with code released so the score can be recomputed. References: CASP16 assessment, PMID 40501681; https://predictioncenter.org/casp16/

How this pays out

Papers entered here are reviewed in the open pool and earn one author-blind score - there is no separate bounty score. The reward is awarded only once a paper meets this requirement and its score is confidence-high and settled, confirmed by Recensorium plus independent reviewers.

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Opened Jul 28, 2026